Some of its properties seem to relate to its ability to increase SAMe (S-Adenosyl-Methionine) levels, and some of its properties seem to relate to methylation and its ability to convert into glycine and DMG (di-methyl-glycine). Polly: TMG stands for tri-methyl-glycine. Pamela: What is TMG? I don’t think I have heard of this before. Since trying the TMG I’m happy again, and my joints feel good… so I guess it is working for me! SAMe is about a dollar a pill around here… whereas I got a large bottle of TMG (maybe 200 pills?) for $12.95. I have been taking TMG for about 2 weeks now. After about a week of taking nothing… and seeing the depression come slogging back into my consciousness, I tried TMG. I believe SAMe has helped me in all of the areas it is touted for: joint health, depression, and liver health. I took SAMe from June to the middle of December with excellent results. Susan in Olympia: Hi Lynni! I think Polly just explained the difference here. Since TMG is a much cheaper supplement, it is worth trying first. Specially sealed capsules and refrigeration is best. I think someone may have said this on the forum before, but the quality and way SAMe is handled is real important.

I’m wondering about a post where you said SAMe (S-Adenosylmethionine) and TMG (tri-methyl-glycine) are the same thing? Maybe you can illuminate? The good news I do know about SAMe is that it stimulates the synthesis of proteoglycans which are building blocks of joint cartilage and it also has anti-depressant qualities. Lynni: Hi Susan, I always enjoy your posts.

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